I had an idea for a character design but I can't implement it. I wanted to make a superhero whose powers came out of his guitar. Of course there isn't a way to implement it but I'd hope this might inspire someone in the game design department. It wouldn't have to just be a guitar. You could also make animations for any instrument like a saxophone, or flute, violin/fiddle, etc. Or the hero could be a vocalist & the powers come out of his mouth.

If you're afraid it'd look corny, that's totally okay. Corny works for this. The items and animations should not be limited to one kind of power set. This could work for sonic based percussive powers, or mind-controlling hypnotic powers, or even elemental control powers like earth, fire, plants, cold, acid, etc. The instrument could also double as a shield or be used in melee combat.